User manual LEICA FL400 BROCHURE

[. . . ] Leica FL400 Invisible Becomes Visible Living up to Life Pioneering Fluorescence Innovation The development of fluorescence microscopy has a long tradition at Leica Microsystems, dating back to the beginning of the 20th century. An important contribution to biological research, fluorescence science now integrates with the technology of the surgical microscope to provide state-of-the-art oncological fluorescence. [. . . ] The Leica CAN bus controls the type of illumination, the observation filters for different fluorescence applications, and an optional mode-controlled video camera specifically aligned for fluorescence. 8 excitation spectrum eye sensitivity spectrum 0. 4 emission spectrum 400 500 600 7 0 0 /nm 3 IntenseBlue TM Using two light sources (Leica M525) or a high efficient 400W light source (Leica M720), the Leica FL400 offers the best excitation and bright fluorescence of the protoporpherin. Furthermore, the system supports the surgeon with longer resection cycles in the blue light mode, without the eyestrain of frequent changes to white light. Leica M720 FL400 illumination module The PDI Application Surgeons familiar with Photo Dynamic Imaging (PDI) comment that it is very easy to use. The patient orally receives the 5-ALA dissolved in water, thus placing little strain on the patient, and has almost no side effects. Tumor resection can be performed not only in white light mode but also in blue light mode. Blue light mode requires sufficient brightness in order to resect the residuals of the tumor, which always appear red or pink under blue light. The Leica FL400 used for PDI reveals many new possibilities ­ its potential is not yet fully realized. Overall, it represents an outstanding new, straightforward method of intraoperative tumor resectioning. Malignant glioma, white light mode Malignant glioma, blue light mode Pictures taken with Leica FL400 5-ALA Operation 5 The Leica FL400 System The intensified and homogeneous excitation light of the Leica M525 OH4 with the Karl Storz D light C or the Leica M720 OH5 with 400W Xenon power offers a bright and clear fluorescence view. A patented long pass filter switched into the observation beampathes provides a well-adjusted observation and a perfect photo dynamic signal. 6 The Best Possible Image The fluorescence technique The Leica M720 OH5 and Leica M525 OH4 can be easily upgraded to use blue light fluorescence. The illumination systems, the observation filters and an optional blue mode-optimized video camera interact automatically with a simple push of a button found on the pistol grip of the surgical microscope. This offers bright blue illumination and an easy and ergonomic change of the observation modes. The Leica M720 and Leica M525 surgical microscopes The Leica M720 OH5 and Leica M525 OH4 with integrated Leica FL400 5-ALA fluorescence module offer the easiest movement, best ergonomics and highest quality optics of any surgical microscope on the market today. Leica's premium OptiChromeTM Optics provides outstanding contrast, sharpness, resolution and color fidelity. [. . . ] We have developed five brand values to live up to this tradition: Pioneering, High-end Quality, Team Spirit, Dedication to Science, and Continuous Improvement. For us, living up to these values means: Living up to Life. [. . . ]